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   Symposium on Computational Challenges in Bioinformatics  
 

 
INTRODUCTION

Understanding biological processes in terms of their underlying physical and chemical processes is one of the continuing grand challenges of science and holds vast potential for improving human well being. In this direction, the Human Genome Project was undertaken with the goal to advance fundamental biological understanding and provide the basis for future advances in biotechnology, agriculture, environmental remediation and quality, health and medical practice.

The bottleneck in the area is the challenge of analyzing the phenomenally enormous amount of accumulated data, necessitating the need for high performance computing. It is well known that many of the problems in Bioinformatics can be addressed only with compute power, which is well beyond the teraflop scale.

It is a fact that modeling multiple levels of biological complexity is well beyond even the next generation of supercomputers, but each increment in the computing infrastructure makes it possible to move up the biological complexity ladder and tackle problems that have been hitherto unsolved. Here, Grid Computing is poised to enable researchers to pool the computing resources at various places to accelerate the research process in Life Sciences. A collaborative research of distributed scientists will assist in solving the mysteries of life, in the treatment of diseases, in developing better crops, leading overall to a better well being.

The symposium, jointly held by C-DAC and IBM Life Sciences, aimed to generate awareness about the High Performance Computing and Grid applications in Bioinformatics and created a forum for researchers to exchange their views on the subject.

 

Bioinformatics@C-DAC

Established in March 1988, as a Scientific Society of the Ministry of Communications and Information Technology, Government of India, the Centre for Development of Advanced Computing (C-DAC), is primarily an R&D institution involved in the design, development and deployment of electronics and advanced Information Technology (IT) products and solutions.

In a decade and a half since its inception, C-DAC has established its brand image as a premier R & D institution of national and international repute working in advanced areas of electronics and information technology and developing and deploying, advanced IT products and solutions for important sectors of economy.

PARAM Padma represents C-DAC's entry into the select league of supercomputing nations. This terascale supercomputing system housed at C-DAC's Terascale Supercomputing Facility (CTSF) at C-DAC, Bangalore is also the fastest supercomputer in the country, and ranked 171 in the Top 500 list of fastest supercomputers in the world. C-DAC's High Performance Computing and Communications (HPCC) software on PARAM Padma effectively addresses the performance and usability challenges of clusters through a high performance flexible software environment. It provides low overhead communication, optimized MPI and a parallel file system with MPI-IO interface to enable applications to scale on large number of clusters. C-DAC's PARAMNet II interconnect switch enables high speed (1.5 GBPS full duplex) and low latency (less than 10 µsec) communication among large number of compute nodes of PARAM Padma.

C-DAC's foray in the area of Supercomputing based Bioinformatics applications has a manifesto to develop, port and optimize codes on the PARAM series of Supercomputers, in the various areas of Bioinformatics like molecular modeling, sequence analysis, comparative genomics and microarray data analysis, and to carry out research in the related areas. C-DAC has interacted with a number of institutions engaged in this fast emerging area.



Life Sciences@IBM

The IBM Life Sciences Solutions Business Unit provides the IT infrastructure that researchers in biotechnology, pharmaceutical research, genomics, proteomics, and healthcare need to turn data into scientific discovery and new treatments for disease.

IBM Life Sciences is dedicated to rapidly bringing leading-edge technology out of the laboratory and into the marketplace for customers and Business Partners in the fields of pharmaceutical research, biotechnology, genomics, proteomics, health care, and academic research.

Combined with IBM's core strength in providing robust technology and global services, the IBM Life Sciences business unit delivers innovative, scalable infrastructure solutions that are unique to the life sciences industry. The IBM commitment to the Life Sciences industry is defined by:

" The active pursuit of strategic business partnerships with life sciences companies whose complementary skills, knowledge, and resources can help build value-rich solutions for the industry.

" The formation of a dedicated IBM Global Life Sciences Consulting and Solutions practice to focus IBM service capabilities, expertise, and intellectual capital on helping customers and Business Partners to migrate their R&D units into even more efficient and competitive operations.

" Two key research centers, the IBM Computational Biology Center and the IBM Deep Computing Institute, housing teams of scientists working on projects involving computational biology, chemistry and material science. Long-term projects at the IBM Computational Biology Center foster IBM collaboration with life sciences companies to bring scientific expertise directly into the development of life sciences solutions.

 

SCIENTIFIC PROGRAMME

The technical sessions comprised of invited talks from internationally recognized professionals in the area of genomics and bioinformatics. The talks addressed the computational challenges in the areas of sequence analysis, comparative genomics, molecular modeling and algorithm development followed by demos of some of the bioinformatics software that had been developed and ported on the PARAM Padma system.

 

For further details, please contact:

Ms Mira Panickar, Secretary,
Symposium on Computational Challenges in Bioinformatics
Centre for Development of Advanced Computing
Pune University Campus
Ganesh Khind
Pune - 411 007
India.

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